Promethazine is metabolized with the liver to a number of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing during the urine.

Promethazine HCl and Codeine Phosphate Oral Remedy should be applied with caution in people with impairment of hepatic perform, and individuals should be monitored intently for respiratory melancholy, sedation, and hypotension.

Respiratory complications (respiratory depression)that can lead to Dying and opioid withdrawal can take place if you start taking or cease getting other medicines whilst using Promethazine Hydrochloride and Codeine Phosphate Oral Option, including:

Everyday living-threatening breathing troubles (respiratory melancholy). Promethazine Hydrochloride and Codeine Phosphate Oral Solution might cause respiration complications (respiratory melancholy) which will take place Anytime through cure and may result in Loss of life. Your risk of respiration difficulties is greatest when you initially get started getting Promethazine Hydrochloride and Codeine Phosphate Oral Option, are having other medicines that might cause respiratory complications, have specified lung challenges, are elderly or have sure other health issues.

Promethazine HCl Oral Solution administered into a Expecting woman in two weeks of shipping could inhibit platelet aggregation from the newborn.

If this SPL has inactivated NDCs listed with the FDA initiated compliance motion, They are going to be specified therefore.

The results of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complex.

Long-phrase animal experiments have not been carried out to evaluate the carcinogenic possible of Promethazine, nor are there other animal or human details concerning carcinogenicity, mutagenicity, or impairment of fertility using this type of drug. Promethazine was nonmutagenic while in the Salmonella test system of Ames.

Promethazine HCl Oral Alternative may perhaps decrease seizure threshold. It ought to be made use of with click here caution in people with seizure disorders or in people who are using concomitant remedies, including narcotics or community anesthetics, which may also impact seizure threshold.

Life-threatening respiratory despair and Dying have transpired in children who obtained codeine. The vast majority of reported cases occurred following tonsillectomy and/or adenoidectomy, and several of the youngsters experienced evidence of staying an extremely-fast metabolizer of codeine resulting from a CYP2D6 polymorphism [see Warnings and Safeguards (five.

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Promethazine shouldn't be used in pediatric patients fewer than two a long time of age because of the possible for fatal respiratory melancholy.

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Promethazine is commonly distributed in human body tissues. Promethazine has substantial protein binding with about 80 to 93% of promethazine sure to plasma proteins. Promethazine passes the blood Mind barrier plus the placental barrier.